Myograph Study Possibilities

The mentioned areas of investigation are just a few, as the myograph systems allows many possibilities for investigation of vascular reactivity and functions

Basic Properties

- Small vessels
- Large vessels
- Isometric wall tension measurements
- Measurements of wall (media) thickness
- Comparative studies of two vessels
- Vessels isolated from biopsies:
Assessment of local vascular reactivity
- Studies on human vessels

Vasoactive Mechanisms

- Endothelium: role of
Endothelium-derived relaxing factor (NO)
Prostaglandin’s
Endothelium-derived hyperpolarizing factor
- Smooth muscle:
role of calcium channels
Potassium channels
- Intramural nerves: role of endogenous transmitters

Receptor Studies

- Localization and characterization of receptors
- Effects of hormones, neurotransmitters and other agonists

Further Possibilities

- Electrophysiological experiments (highly isometric support)
- Fluorescence measurements of intracellular ions and other substances

Pharmacotherapy

- Effect of treatment with e.g. ACE-inhibitors, digoxin or insulin

Physiological Changes

- Aging
- Pregnancy
- Anesthesia

Pathology

- Hypertension
- Atherosclerosis
- Diabetes
- Ischemia
- Tumors
- Heart diseases
- Lung diseases